Santiago, Chile from €575 Roundtrip: American Airlines Flights from Prague

Explore one of South America's most exciting destinations with American Airlines flights from Prague to Santiago starting at just €575 roundtrip. These itineraries include connections in Philadelphia and Miami, with checked baggage and a carry-on included in the fare.

Santiago is a fantastic gateway to Chile's diverse landscapes—from the Andes Mountains and world-class wineries to the colorful port city of Valparaíso and the Atacama Desert.

Highlights:

✔ Roundtrip fares from €575

✔ Flights from Prague (PRG) to Santiago (SCL)

✔ Connections in Philadelphia (PHL) and Miami (MIA)

✔ American Airlines

✔ Checked baggage and carry-on included

✔ Travel in August and September 2026

Example Dates:

27 August - 6 September 2026

14-29 September 2026

14-30 September 2026

Additional dates may also be available.